Modelling Impact and Cost‐effectiveness of Oral Pre‐exposure Prophylaxis in 13 Low‐resource Countries

Oral pre-exposure prophylaxis (PrEP) provision is a priority intervention for high HIV prevalence settings and populations at substantial risk of HIV acquisition. This mathematical modelling analysis estimated the impact, cost and cost-effectiveness of scaling up oral PrEP in 13 countries. These modelling results can inform prioritization, target-setting and other decisions related to oral PrEP scale-up within combination prevention programmes. We caution against extensive use given limitations in cost data and implementation approaches. This analysis highlights some of the immediate challenges facing countries—for example, trade-offs between overall impact and cost-effectiveness—and emphasizes the need to improve data availability and risk assessment tools to help countries make informed decisions.

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